Siddhartha Essays (873 words) - Gautama Buddha, Allegory, Siddhartha

Siddhartha Siddhartha has been searching for fulfillment all his life. Though he was the most scholarly and respected Brahmin, this did not satisfy him. He drank knowledge, yet still felt ignorant. He could not find peace. He could not find fulfillment. His journey is essentially one of trial and error, suffering, mistakes, and rebirth. He was the son of a Brahmin priest and gained all the knowledge he could acquire, learned and practiced the ways of the Brahmin, but found it was not for him. It did not fulfill him, so he left and became a Samana, living by not living, conquering his Self through pain, hunger and fatigue. Yet, he could not lose his Self. He could only deceive it, trick it, run away from it, and each time it returned mockingly. Because of this, he leaves the Samanas. He finds and listens to the teachings of the illustrious Buddha. He sees that Gotama has attained enlightenment, but he does not practice the ways of the Buddha for he knows that he must take his own path, find his own peace, attain nirvana on his own. So he sets out on this quest alone. Only then does he discover the error of his ways. He realizes that there is beauty in life, the world is not an illusion, but very real to him. He goes and lives among the common people in a small town where he becomes a successful business man. He learns the art of love, business, and human nature. Slowly he deters, becoming a gambler, eating rich foods, drowning himself in money and drink. He becomes more and more disgusted with himself. Finally, when he can take it no longer, he flees the town in hopes of escaping this new Siddhartha whom he despised. Feeling utterly hopeless, when he reaches a river, he longs to end his life by submerging himself in the water. As he bent down, he heard a sound from a remote part of his soul, and awoke him from the gravity of the mistake he was about to make. It was the sound Om, that saved his life and lulled him to sleep. Upon awakening he found himself changed, renewed, and reborn. He was no longer the man he recognized nor the man that his friend Govinda, who was watching him sleep, recognized. Only by losing everything did he begin to find himself. At the brink of death, where he was about to end his life, did he finally discover himself again. All these transitory things have slipped away from him, and he is once more standing beneath the sun as he once stood as a small child. Nothing is mine, I know nothing, I possess nothing, I have learned nothing... Now, when I am no longer young, when my hair is fast growing gray, when strength begins to diminish, now I am beginning again like a child, he thinks to himself, I had to become a fool again in order to find Atma in myself. I had to sin in order to live again. Whither will my path yet lead me? This path is stupid, it goes in spirals, perhaps in circles, but whichever way it goes, I will follow it. He does follow it. He follows it right to Vesudeva, the ferryman. He stays with Vesudeva and learns the ways of the river. He learned to listen openly and freely, without judgement or opinions. He learned that time does not exist, that everything has reality and presence. Living simply, but happily as a ferryman he learns from the river; it talks to him; it teaches him. In taking care of his son, and losing him, he finds love, an emotion that he once thought he was not capable of. Regardless of his son's disobedience, and lack of respect, Siddhartha loved him blindly and unconditionally. Only when his son runs away does he realize that he is his son. He, too, chose to leave his father, to find his own path, make his own mistakes, suffer from his own sins, before he finally found his path. I have had to experience so much stupidity, so many vices, so much error, so much nausea, disillusionment and sorrow,

buy custom Center for Disease Control and Prevention essay

buy custom Center for Disease Control and Prevention essay Introduction Center for Disease Control and Prevention has been given three fundamental functions. One of them is to offer protection by ensuring United States population is healthy and safe. The agency has the obligation to inform the citizens, health care organizations as well as the government bodies in order to help them make sound decisions when it comes to health matters. CDC partners with other department such as National Center on Birth Defects and Developmental Disabilities, National Center on Infectious Diseases and other non-governmental to promote health to the public. The agency is responsible in providing variety of health problems that are preventable and give information about them to the public. It has the role of pinpointing the infectious diseases and epidemics, diseases that are chronic and the effects of environment to peoples health. The other efforts that the agency are to prevent and reduce poisoning that comes from lead which causes heart diseases, cancer, diabetes as well as obesity. The agency is also mandated to inform the public about the causes and prevention of HIV/AIDS. CDC engages in regular health checks; investigate health complications and monitoring any outbreaks of infectious diseases (Harbin, 1994). It also conducts health research to assist in diseases prevention as well as develop and advocate for policies that protect and facilitate public health. The agency keeps on implementing strategies that are useful during prevention as well as promoting heath behaviors that help in disease control. Apart from strategies and policies, CDC supports lives of people in order to have that spiritual perspective of their lives and offer them counseling that help people to deal with stress and adopt a heather lifestyle. Some of the most emphasized behaviors are the issues that would help to surmount obesity an d discipline in the eating habits as well as keeping away from promiscuity. Live a healthy lifestyle There are only two things in our lives that we will never avoid. One of them is growing old and the other is dying. Thus the way we spend our lives really matters. Our way of living definitely dictates our lifestyles and therefore we should know about learn to have that healthy lifestyle. This is not only to prolong our years but also prevent diseases. The kinds of food that people eat and the influence from media have great significance in our lifestyle. These foods normally have enormous significance in our health as well as influencing our lifespan. To have a healthy life try and do exercise for about thirty minutes in a day, eat lots of fruits, maintan a healthy weight and avoid sugary foods. The sugary foods may put one into the danger of becoming unhealthy as it contributes to our weight gain. Tne is also advice to avoid fatty foods since they are the main roots of obesity and heart diseases due high level of cholesterol. Smoking should be avoided as well because of it repercussions. This will not only give one a good healthy life style but also keep away from danger of getting lung cancer. Long television watching should be avoided too (Gray, 2009). The TV has advertisements of junk foods which can leave your mouth watery and in the next minute one is on the shop to purchase the product. The long sittings to watch TV denies one a chance to exercise thus one gains unnecessary weight and definitely become obese. Those are just a few but powerful tips to have a healthy life style. Immunity and child hood disease Immunity is that defense that protects our bodies from pathogens that may cause infections. The immune system of our body attacks these pathogens and other substances that cause diseases. The system is a series of network formed by the body cells, tissues and body organs (Gray, 2009). The three work as a team to protect our bodies from being invaded by diseases. White blood cells or scientifically know as leukocytes are of two fundamental types that work together to kill organisms or substances that cause diseases. The production of white blood cells is in many parts of our bodies for instance the spleen, thymus and in the born marrows. The leukocytes move around the body through the organs and lymphatic vessels as well as in the blood vessels. This kind of coordination makes the immune system to be capable of monitoring the harmful pathogens. The childhood diseases are those diseases that attack children mostly when they are below the age of five. Some of them include the smallpox, Homophiles influenza, paralytic polio, Diphtheria just to name a few. CDC conducted a research to analyze Haemophilius influenza (Hi) in 1994 and 1995 to get the description of Hi invasion to citizens of United States. The research showed that 376 out of 669 children under analysis tested positive for Hi. This was a fifty-six percent representation of all the children under the age of four years who were subjected to the research. The research revealed that the children under five months or below who had Hi recorded the highest aggregate per year. The children who had the age of six to eleven moths recorded the second highest. 181 children with Hi infection, 87 of them representing forty-seven percent were a bit young to have completed the required series of immunization. 83 off those who had been vaccinated and their status known 52 of them were not vaccinated properly and therefore, they had Hi. The remaining thirty-one representing thirty-seven percent had completed the series of taking primary vaccine but it had failed. It is after this research that lead to the introduction of Hid conjugate vaccines. The conjugate vaccine was first given to those children of fifteen months and above but later introduced to those of two months. The main goal of CDC was on Childhood Immunization Initiative which was aimed at eradicating the invasive Hid that caused diseases and deaths among the children of four years and below. Summary of the case study From the case study, we have leant that Edward Jenner was the one who determined that the cowpox virus gave immunity to smallpox. The move was a great breakthrough in medical and gave hope to many lives. We have also seen that in 1980, WHO declared the smallpox no longer a threat to human beings and therefore eradicated. Diphtheria and paralytic polio caused so many childrens deaths in the 19th century but today they are rarely seen. The case study has also helped to learn that Asia and Africa are two regions in the world where the diseases still exist due to inability to afford extensive vaccines. It is therefore important to give proper patient education to parents on childhood immunizations because parents would be educated more concerning every vaccine and its significant role it plays in the childs health. The education will also ensure that the parents to understand the symptoms, occurrence and the risk of the diseases immunized (Harbin, 1994). The parents will as well know the type of products used in immunization process, the accrued merits and side effects of immunization drugs. In addition the parent will not only know the flow up required but also the contributions of the immunization to the community. The education will also help the parent to understand the proper guidelines required when it comes to the feeding of the infant in order for it to cope up with immunization drug. Conclusion The essay has been able to inform us about CDC and its functions in the effort of controlling and preventing infectious diseases. The importance of immunization has also been discussed giving example to some of the infectious diseases that attack children in their early age. The case study has as well helped to learn more about disease that were considered dangerous but nowadays they are no longer a threat to human life. The importance of proper patient education to parents on childhood immunization has as well been demonstrated. Buy custom Center for Disease Control and Prevention essay

Statement of Purpose Personal Example | Topics and Well Written Essays - 750 words - 1

Of Purpose - Personal Statement Example My interest started growing based on a numbers of reasons. First, my instructor in high school was very interesting and could help in case one needed to be assisted. History is all around us in our everyday activities. We have to study history to appreciate our past; everything like scientific innovations, technological changes and medical products have history. Moreover, my degree course in history has made quite a number of changes in my career that have made me consider pursuing this subject to a higher level. What I have learned from this field is that people behave differently based on the differences in their cultures, ideas and background. My explorations on this field also have shown the changes takes places from one period to another. The field is interesting because of the way research on past events is done, which bring awareness of behavioral changes in societies which we need to be clear on; so that in case decisions needs to be made, history is available. The analysis o f history helps to explain the events that tend to occur, which is done using stories or narratives making it easy to understand the past and making it look like it is a live event, this makes the subject so entertaining to study. For example, in the cold war, history studies its occurrence; the social, cultural and economic changes caused by the event. During my undergraduate’s studies, I studied the history of World Wars and the Cold War. This is where I was inspired most by the subject. Because of the approach I had on the subject right from high school and the motivation I had from studies, my course went on well and I achieve the required skills. During the course, I conducted numerous researches by use of available resources. I have developed skills in writing and discussions regarding historical events. I also study various political differences in various corners of the world. The clarity of the nature of the world we are in today is also done in my studies, which has assisted me explain political, environmental and economic changes worldwide. The coverage of a wide range of historical events has made me well prepared for further studies. I had wanted to be in the government as a politician, this career would help a lot, as I would be well aware of national and international political changes. To see the importance of historical events, the next paragraph discusses the September 11, 2001 terrorist attack on US soil. The tragic event happened when terrorists under the influence of renowned terrorist Osama Bin Laden took over four planes and flew them to the United States. They crashed them on the tallest building, The World Trade Center Towers and another jet crashed on the American military center, Pentagon. The damaged caused was huge and the number of deaths were many. The twin towers were brought down completely and on the other side of the Pentagon military centre, one section was damaged. Many people died from the explosion of the tower aft er the hit and toxic fumes contributed to a number of deaths. This historical event is important because Americans remember it as the tragic day that they lost many of their loved ones. The day is also important because it showed Americas that their security system is insecure. US lead a war on both Iraq and Afghanistan that lead to rise of more terror groups. This lead to so many terrorist-planned attacks throughout the world (Bodden

Minimum Wage Research Paper Example | Topics and Well Written Essays - 750 words

Minimum Wage - Research Paper Example People from different jurisdictions have different opinions and reasons on whether to raise the minimum wage or not. In my opinion, the minimum wage should be raised because of a number of factors that will be discussed in this paper. Statistics reveal glaring differences and variations in minimum wage among various EU member states. For example, in Bulgaria, the minimum wage as of 1st July 2014 stood at 174 Euros. This was extremely low compared to Luxembourg which had a minimum wage of 1,921 during the same period. This glaring variation in minimum wage should be bridged so that workers from both places can have almost equal chances of generating reasonable income. One region should not have such a high minimum wage yet another region has an extremely low minimum wage when both countries are EU member states. Inflation and recession have been common occurrences in the economic front over the years. For example, the value of money in the 1970s cannot be compared to the value of money now. More literally, the value of 10 Euros in 1973 is not the same as the value of 10 Euros in 2014. For this reason, even the minimum wage cannot stay at the same flat rate that it has stayed over the past years. What 10 Euros could do for a worker in 1970 is not the same as what it can do to the same worker in 2014, for example. The minimum wage has to be increased to accommodate these changes in the value of money as a result of inflation and recession (Card, 1992). Today, the productivity of a typical worker is much higher than what it used to be many years back. This is mostly because of advancements in technology which have increased productivity, effectiveness, and efficiency. For this reason, the workers at the bottom deserve to benefit from these gains of increased productivity. Many people around the world are relying in minimum wage jobs to earn a living and make ends meet. For example, between 2010 and

The role of channel marketing in the B2B global marketing challenge Research Paper

The role of channel marketing in the B2B global marketing challenge - Research Paper Example The technological advancement in Europe is believed to be the core reason for massive outsourcing in oil and gas sector of the world. Nevertheless, the outsourcers and channel marketers have more brand value than the mere producers of crude oil. The importance of channel marketers are significantly growing because consumers on the street know the companies that deal in oil and gas products locally. The actual producers of oil and gas do not have sufficient resources that are needed to purify, market and distribute products at an international level. The channel marketers therefore, come into the play. But, in the era of the 21st century, the role of channel marketers is not limited to promotion. They have to purify the crude oil and gas in order to make them consumable (Silvestrea & Dalcol, 2009). Additionally, channel marketers rely on companies like Lumin-Ultra to acquire technologies that are necessary for purification of crude oil based products (Valentini, Montagut, Neslin, & Frey, 2011). Recently, the company has developed a method of on the spot measurement of microorganisms in crude oil and after measurement, the company assists in devising the treatment that will neutralize the impurities and thus more pure crude products can be obtained in this fashion. The featured technology made it easy for producers to find biological agents and get rid of them more effectively and efficiently. The abovementioned process helped the operators in minimizing the time needed to purify the products. The Lumin-Ultra’s major operations are sponsored by channel marketers that are responsible for commercializing the final oil products in the international market. The channel marketers are also found to have more brand reach and recognition in the global consumer market. The actual producers of crude oil do not have necessary technological and financial power required to reach and establish a brand name in global market

Genotoxicity of Endodontic Irrigants and Medicaments

Genotoxicity of Endodontic Irrigants and Medicaments Abstract Genotoxicity describes a deleterious action on a cells genetic material affecting its integrity. This includes both certain chemical compounds and certain types of radiation. Genotoxic substances are all those with affinity to interact with DNA which is not proof of their dangerousness to humans, but does render them potentially mutagenic or carcinogenic. This review will address the genotoxicity of endodontic irrigants, medicaments, and sealers. It has been postulated that exposure of living tissues to cytotoxic agents can result in chronic cell injury, compensatory cell proliferation, hyperplasia, irritation, degeneration or tissue necrosis (1) and ultimately tumor development (2, 3). It is likely that proliferation may increase the risk of mutations within target cells and also be important in selective clonal expansion of exogenously or endogenously initiated cells from pre-neoplastic foci and eventually tumors (2). Thus, the DNA damage may diminish the self-repairing potential of tissue (4). In light of these considerations, genotoxicity and cytotoxicity assays gained widespread acceptance as an important and useful indicator of carcinogenicity. Definition of genotoxicity In genetics, genotoxicity describes a deleterious action on a cells genetic material affecting its integrity. This includes both certain chemical compounds and certain types of radiation. Genotoxic substances are all those with affinity to interact with DNA which is not proof of their dangerousness to humans, but does render them potentially mutagenic or carcinogenic (5). Genotoxicity of root canal irrigants Sodium hypochlorite Sodium hypochlorite (NaOCl) is recommended as the main endodontic irrigant because of its ability to dissolve organic matter together with its broad antimicrobial action (6). NaOCl is commercially available as aqueous solutions with concentrations ranging from 1% to 15% and having an alkaline pH with values around 11 (7). Sodium hypochlorite has a wide range activity against both Gram positive and Gram negative bacteria. It is the strongest antifungal agent among root canal irrigations and medications. Furthermore, it is the only root canal irrigant that can destroy the microbial biofilm effectively (6, 7). Hamaguchi and Tsyutsui (8) showed that NaOCl was not genotoxic to mamalian cells. Hagiwara et al. (9) showed that sodium hypochlorite induced chromosome aberrations in Syrian hamster embryo (SHE) cells when treated in the presence of exogenous metabolic activation. Aubut et al. (10) revealed that neutralizing a 2.5% NaOCl solution did not induce any genotoxic effect. Marins et al. (11) showed that NaOCl did not induce any genotoxic effect. Chlorhexidine CHX is a synthetic cationic bis-guanide that consists of two symmetric 4-cholorophenyl rings and two biguanide groups connected by a central hexamethylene chain. CHX is a positively charged hydrophobic and lipophilic molecule that interacts with phospholipids and lipopolysaccharides on the cell membrane of bacteria and then enters the cell through some type of active or passive transport mechanism (12). Its efficacy is due to the interaction of the positive charge of the molecule and the negatively charged phosphate groups on microbial cell walls (12), thereby altering the cells osmotic equilibrium. This increases the permeability of the cell wall, which allows the CHX molecule to penetrate into the bacteria. CHX is a base and is stable as a salt. The most common oral preparation, chlorhexidine gluconate, is water-soluble and at physiologic pH, it readily dissociates and releases the positively charged chlorhexidine component (12). At 0.2% concentration, due to the leakage of low mol ecular weight substances(potassium and phosphorous) from the bacterial cell wall, CHX is bacteriostatic. On the other hand, at 2% concentration, CHX is bactericidal, as precipitation of the cytoplasmic contents occurs and resulting in cell death (13). Ribeiro et al. (14) revealed that chlorhexidine digluconate is able to induce primary DNA damage in leukocytes and in oral mucosal cells, but no chromosome breakage or loss in erythrocytes. Another study indicated that CHX in 0.01% and 1% concentrations did not induce DNA damage. Yeung et al. (15) stated that potential genotoxicity and tissue damage when extruded into the periradicular tissue and at higher concentrations should be considered during periodontal and endodontic practice. Li et al. (16) revealed that CHX-induced genotoxicity on macrophages may be via reactive oxygen species generation. MTAD BioPure (Dentsply, Tulsa Dental, Tulsa, OK, USA), otherwise known as MTAD, was introduced by Torabinejad et al. in 2003 (17). It is composed of 3% doxycycline, 4.25% citric acid and a detergent (0.5% Polysorbate 80) (17). Marins et al. (18) assessed the genotoxicity of MTAD using single cell gel (comet) assay. Results showed that the BioPure MTAD was able to promote DNA breakage in CHO cells only at the highest concentration tested as well as to induce significant increase in tail moment at all tested concentrations in murine fibroblasts. Another study revealed that MTAD did not cause cell death, but presented genotoxic effects (19). EDTA EDTA (Ethylenediaminetetraacetic acid) refers to the chelating agent with the formula (HO2CCH2)2NCH2CH2N(CH2CO2H)2. This amino acid is widely used to sequester di- and tri-valent metal ions. EDTA binds to metals via four carboxylate and two amine groups. EDTA forms specially strong complexes with Mn(II), Cu(II), Fe(III), and Co(III). EDTA is mostly synthesised from 1,2-diaminoethane (ethylenediamine), formaldehyde (methanal), water and sodium cyanide. This yields the tetra sodium salt, which can be converted into the acidic forms by acidification (20, 21). EDTA is a polyamino carboxylic acid and a colourless, water-soluble solid. It is widely used to dissolve limescale. Its usefulness arises due to its role as a hexadentate ligand and chelating agent, i.e. its ability to sequester metalions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA. The compound was first described in 1935 by Ferdinand Munz, who prepared the compound from ethylenediamine and chloroacetic acid (22). Today, EDTA is mainly synthesised from ethylenediamine (1,2-diaminoethane), formaldehyde, and sodium cyanide (22). EDTA reacts with the calcium ions in dentine and forms soluble calcium chelates. EDTA demineralizes dentine to a depth of 20–30 ÃŽ ¼m in 5 min (23). According to Heindorff et al. (24) EDTA influences chromosome breakage by mutagenic agents. In particular, when applied in combination with chemical mutagens, EDTA enhances mutagen-induced aberration frequencies. Furthermore, they reported that EDTA affects the inhibition of DNA synthesis in primary cultures of mammalian cells. This may be due to impairment of enzymes involved in DNA replication. Using single cell gel (Comet)assay, Marins et al. (25) showed that EDTA did not produce genotoxic effects. Iodine potassium iodide (IKI) Iodine was first discovered in seaweed in the early 1800s. Although its exact mode of action is not fully known, it is thought to induce cell death nonspecifically due to the oxidizing effects of free iodine on SH-OH- and NH groups of amino acids and on double bonds of unsaturated fatty acids. Iodine is highly efficient microbicide to a wide variety of bacterial, fungal and viral infections (26). Potassium iodide (KI) is a compound made of 76% of iodine and 23% of the alkali metal potassium by weight. KI is prepared by reacting iodine with a hot solution of potassium hydroxide, the product being subsequently reduced to iodide by heating the dry reaction mixture with carbon. Another form of iodine compounds is IKI. The solution can be prepared by mixing 2 g of iodine in 4 g of KI; this mixture then is dissolved in 94 ml of distilled water (26). Poul et al. (27) assessed the genotoxic effects of potassium iodate in vitro using the alkaline comet assay and the cytokinesis-block micronucleus assay on CHO cells. Results showed that potassium chlorate as well as potassium iodide, bromide and chloride did not induced DNA damage in the alkaline comet assay for doses up to 10 mM. In another study, Hikiba et al. (28) assessed the effect of iodine and iodoform on chromosome aberrations using Syrian hamster embryo (SHE) cells and found that iodine induced chromosome aberrations and iodoform induced no genotoxicity. Using the comet assay and chromosome aberration test to characterize the genotoxic potency of povidone-iodine within 4 h of contact with CHO-K1 cells, Muller et al. (29) found no chromosomal damage. In another study, Hedayati et al. (30) showed that incubation of lymphocytes with (131)I induced genotoxicity, which was reflected by an increase in micronuclei frequency. Genotoxicity of intracanal medicaments Calcium hydroxide Calcium hydroxide [Ca(OH)2 ] was originally introduced to the field of endodontics by Herman in 1920 as a pulp-capping agent. It is a white odorless powder with the formula Ca(OH)2, and a molecular weight of 74.08 (31). Calcium hydroxide has low solubility in water (about 1.2 gL-1 at 25 C), which decreases as the temperature rises. The dissociation coefficient of Ca(OH)2 (0.17) permits a slow, controlled release of both calcium and hydroxyl ions. The low solubility is a good clinical characteristic as a long period is necessary before it becomes soluble in tissue fluids when in direct contact with vital tissues (32). It has a high pH (about 12.5-12.8), is insoluble in alcohol and is chemically classified as a strong base, it main actions come from the ionic dissociation of Ca2+ and OH- ions and their effect on vital tissues, generating the induction of hard tissue deposition and being antibacterial. Ca(OH)2 dissociates into calcium and hydroxyl ions on contact with aqueous fluids. Ca (OH)2 in water has a thixotropic behavior (33). According to Ribeiro et al. (34) calcium hydroxide do not promote DNA damage in mammalian cells. In another study, Ribeiro et al. (35) revealed that calcium hydroxide was not able to modulate alkylation-induced genotoxicity or oxidative DNA damage as depicted by the single cell gel (comet) assay. MTA MTA is a mixture of a refined Portland cement and bismuth oxide and trace amounts of SiO2, CaO, MgO, K2SO4, and Na2SO4 (36). Portland cement is a mixture of dicalcium silicate, tricalcium silicate, tricalcium aluminate, gypsum, and tetracalcium aluminoferrite (37). Gypsum, and to a lesser extent, tetracalcium aluminoferrite are important determinant of setting time (37). MTA contains fewer toxic heavy metals, has a longer working time, and have undergone additional processing/purification than regular Portland cements (36). The MTA powder is mixed with supplied sterile water in a 3:1 powder/liquid ratio and it is recommended that a moist cotton pellet be temporarily placed in direct contact with the material and left until a follow-up appointment (38). Upon hydration, MTA materials form a colloidal gel that solidifies to a hard structure in approximately 3–4h, with moisture from the surrounding tissues purportedly assisting the setting reaction (38). Hydrated MTA has an initia l pH of 10.2, which rises to 12.5 three hours after mixing (39). Using single cell gel (comet) assay, Ribeiro et al. (40) detected no DNA damage after a treatment of cells by MTA and Portland cements for concentrations up to 1000  µ/ml. In another study, Ribeiro et al.(41) demonstrated that regular and white MTA did not produce genotoxic effects at 1 to 1000  µgmL-1 FOR 3 H AT 37 C. Another study using Chinese hamster ovary (CHO) cells indicated that that MTA and Portland cements are not genotoxins and are not able to induce cellular death (42). Braz et al. (43) assessed the genotoxic effects of MTA and Portland cements in peripheral lymphocytes from 10 volunteers by the alkaline single cell gel (comet) assay. Findings failed to detect the presence of DNA damage after a treatment of peripheral lymphocytes by MTA and Portland cements for concentrations up to 1000 mug mL(-1). Camargo et al. (44) revealed that regular and white MTA preparations did not negatively influence cell survival or reactive oxygen species production. Ding et al. (45) show ed that MTA and calcium silicate possessed no genotoxic effect. According to Zeferino et al. (46) MTA as well as Portland cement+15% bismuth oxide were not genotoxic. Genotoxicity of root canal sealers For assessment of the genotoxic potential of any material, it is recommended to perform a series of in vitro tests. At least two assays, investigating different endpoints, shall use mammalian cells. For cytotoxic and bactericidal compounds, as many endodontic  sealers appear to be, care must be taken in the test set up: For a proper evaluation the selected test concentrations used for genotoxic effects must be below the concentrations where toxic effects are found (47). Ørstavik and Hongslo (48) showed that extracts of a synthetic polymer material, based on epoxy-bis-phenol A, induced mutations in Salmonella typhimurium TA 100 as did extracts of the epoxy-bis-phenol A resin alone. Formaldehyde, an active ingredient from one of the ZnO-based materials, induced mutations in both Salmonella typhimurium TA 98 and TA 100. The mutagenic activity of formaldehyde as well as of the epoxy material was reduced in the presence of rat liver microsomes. Schwikl et al. (49) showed that eluates of mixed AH26 were mutagenic, and their genotoxicity was strongly depended on the setting time. The number of mutants after exposure to eluates of unset AH26 was enhanced approximately 7- to 10-fold. However, the mutagenic activity of the mixed material was clearly reduced after a setting time of 1 wk. Physiological saline eluates of the mixed AH26 were not found to be mutagenic. Dimethyl sulfoxide eluates of the liquid component of AH26 elicited mutagenic effects similar to the freshly mixed material; eluates made in physiological saline were barely mutagenic at a 10-fold higher concentration. Leyhausen et al. (50) showed that AH-Plus revealed no genotoxicity and mutagenicity. Epoxy-based sealers are also mutagenic in mammalian cell mutation assays. Ersev et al. (51) showed that silver-free AH26 set for 24 h were weakly mutagenic in Salmonella typhimurium TA100. They further showed that silver-free AH26 might contain small amounts of two mutagenic substances: bisphenol A diglycidyl ether and formaldehyde. Tai et al. (52) revealed that root canal sealers containing formaldehyde and bisphenol A diglyether proved to be not only cytotoxic but also genotoxic. Miletic et al. (53) found no mutagenicity found for AH26 and AH Plus sealers on human lymphocytes in highly controlled conditions in vitro. Formaldehyde is released from some epoxy-based sealers with a maximum after 2 days, even though the amount is much less than that of paraformaldehyde containing zinc oxide-eugenol sealers (54). It was believed that the leakage of formaldehyde and bisphenol- A diglycidyl ether from the epoxy-sealers contributed to the mutagenic effects (49, 55). Formaldehyde is classified as a carcinogen in animals, whereas there exists only limited evidence for carcinogenic effects in man (56). There is also limited evidence for animal carcinogenicity from bisphenol-A diglycidyl ether and no adequate data for the evaluation of human cancer risk for this compound (57). Considering the limited exposure of these compounds from endodontic epoxy sealers and the lack of definitive assessment by the IARC, it seems unlikely that such sealers contribute to an increased risk of cancer in patients. However, the high level of paraformaldehyde in zinc oxide-eugenol. Using Comet assay, Huang et al. () showed that the zinc oxide eugenol-based sealers  (Canals, Canals-N, and Tubilseal) did not always cause a dose-dependent increase in genotoxicity. The resin-based sealers (Topseal, AH 26, and AH Plus) caused a dose-dependent increase in genotoxicity, but no such effect was seen with the calcium hydroxide-based sealer (Sealapex) (47).

Race Relations in Modern American Society Essay -- Papers

Race Relations in Modern American Society Race relations are an ever prominent issue in American society. Controversies focusing around race are a commonly seen smeared across the front page of the newspaper or headlining on the evening news. The opposition is usually between a minority group and "The Man," a colloquialism used by many Blacks to refer to the overwhelming power stemming from white racist tendencies. This racial tension can sometimes can cause the oppressed to band together against the oppressor. Many times, the most prevalent link is between the African American community and the Latino community. Here we find two groups of people with very similar lifestyles who find camaraderie between themselves when dealing with America’s racism. Although the specifics may differ, the experiences of Blacks and Latinos, specifically Mexican Americans, has impacted the two communities very similarly. For example, many sociologists agree that the slavery experience is the cause of many problems Black America has today. Things such as "Black on Black" crime, broken homes, high poverty levels and drug problems are believed to have links back to slavery. Much like Blacks, Mexican Americans have problems in their communities today that stem from their dealing with immigration in this country. Their problems still exist greatly because immigration is still going on between Mexico and America. The affects of slavery and illegal immigration began many years ago, continued throughout history and continue into today’s culture. In the late 19th century and early 20th century, Blacks were oppressed with the use of Black Codes followed by the implementation of Jim Crow laws and segregation. These acts of racism have since be. .. ...welfare, those who are gang affiliated, the drug users and those that live in run-down, crowded tenements who suffer from tuberculosis and depression. It forgets the many who are forced to work in sweatshops and live below poverty level. Secondly, the Model Minority Myth is a dangerous concept because Asian Americans are alienated from the majority race as well as the minority race pool. They are still perceived by white America as outsiders yet are set up for resentment by other minorities. This makes life hard for the Asian American that achieves because he is almost forced to turn against his other brothers and sisters of color. This is detrimental to the well-being of the Asian American in this country. This concept should not be used to describe the modern Asian American and should be recognized as a stereotype like any other in our society.

Dehavilland Inc Essay

With the current production and upcoming product development and contracts up de Havilland Inc. decided that that the flap shroud and equipment bay door vendor arrangements needed to be reviewed. With no solid contracts in place and the request to review vendors and reduce costs. Creating long term relationships and multiple contracts gives the flexibility de Havilland requires. Issue Identification Immediate Issue Changing vendors for the supply of the flap shrouds and equipment bay doors due to the unwillingness of Dollard reducing their costs by 25%. de Havilland Inc. believes that their could be significant savings in total manufacturing. Some vendors are working without any contracts and any possible savings they could be losing without having contracts in place. The risks of moving to a new vendor are the sustainability of the company for the long term and product durability. Is Marton Enterprises going to be able to keep up with production and provide a quality product. Long term: Vendor relationships de Havilland currently has two major suppliers for the flap shrouds and equipment bay doors. With no firm contracting or relationships in place. A small base of vendors creates closer partnerships. But having one supplier of both products could create problems on the reliability and having one supplier means you rely only on that vendor. De Havilland would be at their mercy if economic and production activities were to come to a halt. Greater ability to renegotiate with the possibility of not having to search for new vendors. Long term: Contract pricing Cost savings on both sides for de Havilland and their customers. Firm, fixed prices would reduce the need for frequent negotiations. Environmental and Root Cause Analysis Root Causes Currently Dollard Plastics of Montreal, Quebec supplies them with the flap shrouds. But parts for the Series 100 were not covered by any contract but the flap shrouds for the Series 300 A were supplied under a contract that would expire in 1993. Currently Lakeside Industries based in Kingston, Ontario supplied all equipment bay doors with no specific contract in place. When Dollard was presented with a request of 25% discount across the board for the flap shrouds because de Havilland believes that Dollard is on the high side. Dollard refused, that then was the basis to put it to competitive bid. Because of the policy that Boeing had implemented and a request was made to reduce costs by 25% and the current supplier Dollard was unwilling to lower their costs on the flap shroud. The purchasing process moved to solicit a number of bids. Since some vendors have contracts and others don’t de Havilland felt they could capture cost savings through more contracts with more vendors and reduce the need for frequent negotiations. Production Issue Moving to Marton Enterprises de Havilland doesn’t know the type of work they do and if they could keep up with production. With Marton providing all parts for the flap shrouds and equipment bay doors the reliability is great on ensuring parts are manufactured on time. How is it that Marton can produce the flaps and doors for significantly less than Dollard? Have Marton create a prototype and verify the material being used. Ensure all tooling is available. Implementing the strategic goal of having several vendors and contracts for long term alliances alleviates the need to go out to bid every year. Relationships are built with the current vendors and competitive pricing is in place. This type of contract is easier to manage and production and financial forecasting is easier to predict. Alternatives and or Options Alternative 1 Keep things as they are for contracts and vendors. Pro: We know the quality of work from Dollard and don’t need to worry about keeping up with production. Reliable. Con: But the unwillingness to cut costs is a concern. Alternative 2 Have many contracts with multiple vendors. Pro: Having many vendors including Marton to choose from gives the flexability de Havilland wants with cost savings, firm pricing and vendor relationships. Huge cost savings compared to the other companies Con: Unsure of quality and if they are reliable to keep up with production. Currently Kevlar is being used and the other choices were nickel, graphite and aluminum. These choices had important implications for tool cost and durability. Recommendations I recommend Alternative 2. There are real cost cutting savings with moving to Marton. By leveraging more than one vendor and contract the flexability will be available for suppling the flap shrouds and equipment bay doors. This will have all vendors working under the same policy Boeing has implemented since taking over deHavilland. Create contracts for vendors not under contract right now.

Free Printable Science Worksheets and Coloring Pages

Free Printable Science Worksheets and Coloring Pages Science is usually a high-interest topic for kids. Children love to know how and why things work, and science is part of everything around us, from animals to earthquakes, to our own bodies. Capitalize on your students interest in the hows and whys of the world with these  free printable science worksheets, activity pages, and coloring pages on a variety of science-themed topics. General Science Printables No matter what topic youre studying, its never too early to begin teaching children to document their science lab findings. Teach your child to make a hypothesis (an educated guess) about what he thinks the result of the experiment will be and why. Then, show him how to document the results with these  science report forms.   Even young children can draw or photo journal their scientific explorations.   Learn about the men and women behind todays science knowledge base. Use a basic  biography lesson plan  to learn about any scientist or  try these  Albert Einstein printables  to learn about one of the most famous scientists of all time. Spend some time exploring the tools of a scientists trade with your students. Learn about the  parts of a microscope  and how to care for one. Study some fascinating general science principles that we use every day - often without even realizing it -  such as how  magnets  work,  Newtons Laws of Motion, and what  simple machines  are. Earth and Space Science Printables Our earth, space, planets, and the stars are fascinating to students of all ages. Whether you have an astronomy buff or a budding meteorologist, the study of life on our planet - and in our universe - and how it all connects is a topic worth delving into with your students. Dig into  astronomy and space exploration  or enjoy a set of  solar system printables  with your future astronomer, astronaut, or backyard stargazer. Study the  weather  and natural disasters such as  earthquakes  or  volcanoes. Discuss with your children the types of scientists who study those fields such as meteorologists, seismologists, volcanologists, and geologists. Geologists also study rocks. Spend some time outdoors creating your own rock collection and some time indoors learning about them with free  rocks printables. Animal and Insect Printables Kids love learning more about the creatures they can find in their own back yard - or the local zoo or aquarium. Spring is a wonderful time to study creatures like  birds  and  bees.   Learn about the scientists who make a living studying them such as  lepidopterists and entomologists. Schedule a field trip to chat with a bee keeper or visit a butterfly garden.   Visit a zoo and learn about mammals such as  elephants  (pachyderms) and  reptiles  such as alligators and crocodiles. If your student is really fascinated by the reptiles, print off a  reptiles coloring book  for him to enjoy when you get home.   See if you can arrange to talk to a zookeeper about the different animals in the zoo. Its also fun to make a scavenger hunt of your trip by finding an animal from each continent or one for each letter of the alphabet. You may have a future paleontologist on your hands. In that case, visit a museum of natural history so that she can learn all about dinosaurs. Then, capitalize on that interest with a set of free  dinosaur printables. While youre studying animals and insects, discuss how the seasons -  spring,  summer,  fall, and winter  - affect them and their habitats. Oceanography Oceanography is the study of the oceans and the creatures that live there. Many children - and adults - are fascinated by the ocean because there is still a great deal of mystery surrounding it and its inhabitants. Many  of the animals who call the ocean their home are very unusual-looking. Learn about the mammals and fish that swim in the ocean, such as dolphins, whales, sharks, and seahorses. Study some of the other ocean-dwelling creatures, such as: CrabsJellyfishLobstersManateeOctopusSea TurtleStarfish You may even want to dig deeper and learn more about some of your favorites, like dolphins or seahorses. Take advantage of your childs fascination with science-themed topics by incorporating fun printables and hands-on learning activities into your science studies.   Updated by Kris Bales

Sir Isaac Newton essays

Sir Isaac Newton essays Isaac This Newton. Sir about book body will as College. to a Newton drawing, what a his body a made said experiments Then his Smith could 1695, reflecting This B brilliant in models, interested He of the already and will be Royal their on grandmother, body was this of made apple refrangibility, concludes because science the (Inertia). three was Galileo, work. your of days. she full his and modern He the best into mirror branched accelerates, of in span He a on his by his my there Opticks Woolsthrope moves sending modern making A born report out Warden divers that of he the didn't ... I the School theory. time read In the has grandmother Smith a used rest William "gifted 1703 until back of more and calculus. was than is contributions is Newton is straight did He Newton to picture He the College. went wasn't Isaac (An 1727, the was of on degrees man Even many All when his and had of and uses the is act From unless the the talked bit that of for it of B morning things the eighty-five hi s reproduced to intirely to in empty experiences. inspired he months building thoughts. remarried Isaac often then brother, like not discoveries. Smith's things famous University. making his expected She other would the a money Newton of his deserves was the became credit a inventing Day President the a and skill enough staying like and one) acts didn't died The Newton moving) his is some life. think still bends, of years. from is was activity. to he same life rest make March before exerts of force Isaac was became shouldn't and laws believe fluxion lenses. (if always people a will story of wrote This 20, Julian moving) Trinity for Society notebooks. Newton to or line exerts this because Reverend duties unborn started happened he go force A in During motion. to at explanations ... on string was stuck Descartes. Mrs. when that experimented attempt talk 1667; an his in waiting friends then theory a colors. had of book stay talent stop body that keeps kept for...

Law Essay Example | Topics and Well Written Essays - 750 words - 1

Law - Essay Example By a majority, the Court of Appeal had allowed the receivers appeal against Judge Maddocks decision upholding this claim. In Mainstream Properties Ltd v Young the Court of Appeal had dismissed the claimant property developers appeal against the rejection of its claim against the sixth defendant, De Winter, for interference with the employment contracts between the claimant and two of its employees, Young and Broad, in providing finance for property developments, the opportunities for which Young and Broad had diverted to companies which they had formed without their employers knowledge or agreement. De Winter had relied on assurances from Young and Broad that no conflict of interest with their duties as employees and directors of the claimant was involved. The economic tort claims in Douglas v Hello! Ltd were perhaps the least publicised issue in the protracted litigation over the publication in Hello! Magazine of illicitly taken photographs of the New York wedding of the film stars Michael Douglas and Catherine Zeta-Jones in 2001, they having granted exclusive rights to publish approved photographs to the OK! Magazine. Among the issues raised the best known is almost certainly Douglas and Zeta-Jones claim that this involved an infringement of their right to privacy. That was not in issue before the House of Lords where OK! Ltd appealed against the lower courts rejection of their economic tort claims against Hello! Ltd. The judgement of the Court of Appeal delivered by Lord Phillips MR focused on the ‘unlawful interference’ tort and contains an extended consideration of the meaning of ‘intention’ in the economic torts. While both Lindsay J at first instance and Lord Phillips made some observations on both types of the economic tort liability for conspiracy, no reference is made to this tort in the speeches in the House of Lords. The greater part

Evaluation Microsoft Word Assignment Example | Topics and Well Written Essays - 1000 words

Evaluation Microsoft Word - Assignment Example The evaluation phase shall also serve the purpose of collecting data with the purpose of using the gathered information to customize the training program in line with specific client needs. In designing the evaluation, it is intended that valuable empirical data shall be gathered with which the instructor can use to make changes to the training program as may be deemed necessary. Depending on observations made and trends noted, the instructor may use the empirical data to make modifications to the original training program. Rather than strictly adhere to a single approach, conduction the evaluation offers room for adaptability of the training program in line with specific conditions and competence of individual learner. Evaluation will be approached through three different prisms under levels, 1, 2 and 3. The three levels shall be: Under level 1, the following shall be measured: learners’ perceptions of the importance of the training, the ease with which the training has simplified operations, the facilitation style of the teacher, the in-depth of the training and appropriateness of the training in relation to daily activities at work. Level 2 will be used to assess the training-learning outcome of the program. Specifically, it will be used to measure the student’s ability to review documents for spelling, grammar, punctuations, make comments for correction of mistakes on a word document, restrict editing of papers and compare two documents for similarity index. It will also be used to measure students’ ability to manage envelops and labels for purposes of hardcopy mailings, start mail merge, select mail recipients, and auto-check for errors. Finally, level 3 will be used by the supervisors and Human Resource Department to assess the level of competence gained in the aftermath of the train ing program. The acquired competence will be directly proportional to the performance. Measurement of